Compound Detail
CHEMBL5277633
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Basic Information
| ChEMBL ID | CHEMBL5277633 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UFRALLBVADGIFD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.9
MW (Da)
5.44
ALogP
5
HBA
1
HBD
52.0
PSA (Ų)
0.51
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha CHEMBL1795194 | IC50 | 7.7 | 7.7 | 19.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | IC50 | = | 19.95 | nM | 7.7 | Inhibition of recombinant PI5P4Kalpha (unknown origin) expressed in Escherichia ... | 37252102 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 1 |
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine