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Compound Detail

CHEMBL5279500

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NCCCCCCCCCCCCNc1ccnc2cc(C(F)(F)F)ccc12

Basic Information

ChEMBL ID CHEMBL5279500
Phase Preclinical
Structure Type MOL
InChI Key OIDJYBOWCQAHTA-UHFFFAOYSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

395.5
MW (Da)
6.53
ALogP
3
HBA
2
HBD
50.9
PSA (Ų)
0.38
QED
1
Ro5 Violations
13
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H32F3N3
MW 395.51
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.80

Activity Summary

IC50 4 meas. best 4.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Molecular identity unknown
CHEMBL612546
IC50 4.3 4.3 50000.0 1
Pseudomonas aeruginosa
CHEMBL348
IC50 4.2 4.2 63000.0 1
Serratia marcescens
CHEMBL614593
IC50 4.2 4.2 63000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34626877 10.1016/j.ejmech.2021.113864 Serratia marcescens 1
34626877 10.1016/j.ejmech.2021.113864 Pseudomonas aeruginosa 1
37866335 10.1016/j.ejmech.2023.115867 Molecular identity unknown 1
37866335 10.1016/j.ejmech.2023.115867 Serratia marcescens 1
37866335 10.1016/j.ejmech.2023.115867 Pseudomonas aeruginosa 1

Data from ChEMBL 36 via Core Engine