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Compound Detail

CHEMBL5281412

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COc1cc2cc(O)cc(OC)c2c2c(O)cccc12

Basic Information

ChEMBL ID CHEMBL5281412
Phase Preclinical
Structure Type MOL
InChI Key QSFQBDRDJRMLBO-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

270.3
MW (Da)
3.42
ALogP
4
HBA
2
HBD
58.9
PSA (Ų)
0.70
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C16H14O4
MW 270.28
Aromatic Rings 3
Heavy Atoms 20
NP-Likeness 1.29

Activity Summary

IC50 3 meas. best 5.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
No relevant target
CHEMBL2362975
IC50 5.17 4.945 6800.0 2
RAW264.7
CHEMBL612557
IC50 4.62 4.62 24100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29280630 10.1021/acs.jnatprod.7b00619 No relevant target 2
29280630 10.1021/acs.jnatprod.7b00619 RAW264.7 1

Data from ChEMBL 36 via Core Engine