Compound Detail
CHEMBL5283892
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Basic Information
| ChEMBL ID | CHEMBL5283892 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LNMSTPSCCSYARO-HNNXBMFYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
378.5
MW (Da)
3.27
ALogP
5
HBA
1
HBD
79.7
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5A CHEMBL2424504 | IC50 | 9.77 | 7.33 | 0.2 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5A | IC50 | = | 0.17 | nM | 9.77 | KDM5 Enzyme Assay: Full length KDM5A enzyme was expressed and purified inhouse. ... | - |
| Lysine-specific demethylase 5A | IC50 | = | 770.0 | nM | 6.11 | Inhibition of KDM5A (unknown origin ) by Alphascreen assay | 34555614 |
| Lysine-specific demethylase 5A | IC50 | = | 770.0 | nM | 6.11 | Inhibition of KDM5A (unknown origin ) demethylase activity | 34555614 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34555614 | 10.1016/j.ejmech.2021.113855 | Lysine-specific demethylase 5A | 2 |
Data from ChEMBL 36 via Core Engine