Compound Detail
CHEMBL5286364
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Basic Information
| ChEMBL ID | CHEMBL5286364 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RKVUWIUUOBNFHA-PTNGSMBKSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
351.8
MW (Da)
3.08
ALogP
4
HBA
2
HBD
77.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.96
Ki 1 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein CHEMBL1169598 | Ki | 7.05 | 7.05 | 90.0 | 1 |
| Influenza A virus CHEMBL613740 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein | Ki | = | 90.0 | nM | 7.05 | Inhibition of Influenza A virus N-terminal domain of PA endonuclease by fluoresc... | 34591488 |
| Influenza A virus | IC50 | = | 1100.0 | nM | 5.96 | Antiviral activity against Influenza A virus A/PR/8/34 (PR8) strain infected in ... | 34591488 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34591488 | 10.1021/acs.jmedchem.1c01215 | Polymerase acidic protein | 1 |
| 34591488 | 10.1021/acs.jmedchem.1c01215 | Influenza A virus | 1 |
Data from ChEMBL 36 via Core Engine