Compound Detail
CHEMBL5286838
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Basic Information
| ChEMBL ID | CHEMBL5286838 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XIOGALHZYZVCEI-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
3.56
ALogP
4
HBA
0
HBD
59.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Free fatty acid receptor 4 CHEMBL5339 | EC50 | 8.28 | 7.4733 | 5.3 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Free fatty acid receptor 4 | EC50 | = | 5.3 | nM | 8.28 | Agonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assa... | 33843223 |
| Free fatty acid receptor 4 | EC50 | = | 60.0 | nM | 7.22 | Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accu... | 33843223 |
| Free fatty acid receptor 4 | EC50 | = | 120.0 | nM | 6.92 | Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium a... | 33843223 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33843223 | 10.1021/acs.jmedchem.0c01002 | Free fatty acid receptor 4 | 3 |
Data from ChEMBL 36 via Core Engine