Compound Detail
CHEMBL5287858
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(N)C(=O)NC1CSCc2cc3cc(c2)CSCC(C(=O)NC(C)C(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CSC3)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(Cc2ccccc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL5287858 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KECRAMBCZUQJGL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1298.6
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasminogen CHEMBL1801 | Ki | 8.28 | 8.28 | 5.2 | 1 |
| Plasma kallikrein CHEMBL4105792 | Ki | 7.57 | 7.57 | 27.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasminogen | Ki | = | 5.2 | nM | 8.28 | Inhibition of human plasmin using H-d-VLK-AM as substrate assessed as inhibition... | 32066009 |
| Plasma kallikrein | Ki | = | 27.2 | nM | 7.57 | Inhibition of rat recombinant plasma kallikrein using Z-FR-AMC as substrate asse... | 32066009 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32066009 | 10.1016/j.ejmech.2020.112137 | Plasma kallikrein | 1 |
| 32066009 | 10.1016/j.ejmech.2020.112137 | Plasminogen | 1 |
| 32066009 | 10.1016/j.ejmech.2020.112137 | Prothrombin | 1 |
| 32066009 | 10.1016/j.ejmech.2020.112137 | Coagulation factor XI | 1 |
| 32066009 | 10.1016/j.ejmech.2020.112137 | Coagulation factor XII | 1 |
Data from ChEMBL 36 via Core Engine