Compound Detail
CHEMBL5288131
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Basic Information
| ChEMBL ID | CHEMBL5288131 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCUHRHHLUUZJEQ-VNRZBHCFSA-N |
| Parent Compound | CHEMBL5315681 |
| Active Moiety | CHEMBL5315681 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
380.4
MW (Da)
4.78
ALogP
4
HBA
0
HBD
51.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 10.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Translocator protein CHEMBL4552 | Ki | 10.15 | 10.15 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Translocator protein | Ki | = | 0.07 | nM | 10.15 | Displacement of [3H]PK11195 from TSPO receptor in rat brain cortex mitochondrial... | 34254805 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34254805 | 10.1021/acs.jmedchem.1c00379 | No relevant target | 1 |
| 34254805 | 10.1021/acs.jmedchem.1c00379 | Translocator protein | 1 |
Data from ChEMBL 36 via Core Engine