Compound Detail
CHEMBL5288342
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Basic Information
| ChEMBL ID | CHEMBL5288342 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DZIHITUUUPJMOQ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
1
PK Parameters
11
Publications
0
Known Names
Molecular Properties
378.9
MW (Da)
5.44
ALogP
5
HBA
1
HBD
52.0
PSA (Ų)
0.51
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha CHEMBL1795194 | IC50 | 8.0 | 7.5333 | 10.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.1833 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | IC50 | = | 10.0 | nM | 8.0 | Inhibition of recombinant PI5P4Kalpha (unknown origin) expressed in Escherichia ... | 37252102 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | IC50 | = | 10.0 | nM | 8.0 | Inhibition of GST-fused human recombinant PI5P4Kalpha expressed in Escherichia c... | 37859710 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | IC50 | = | 251.19 | nM | 6.6 | Inhibition of PI5P4Kalpha in human HEK293 cells incubated for 60 mins by lumines... | 37252102 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 3 |
| 37252102 | 10.1039/d3md00039g | ADMET | 3 |
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 1 |
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 37252102 | 10.1039/d3md00039g | No relevant target | 1 |
| 37252102 | 10.1039/d3md00039g | Sphingosine kinase 2 | 1 |
| 37252102 | 10.1039/d3md00039g | Mitogen-activated protein kinase 3 | 1 |
| 37252102 | 10.1039/d3md00039g | Tyrosine-protein kinase JAK3 | 1 |
| 37859710 | 10.1039/d3md00355h | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 1 |
| 37859710 | 10.1039/d3md00355h | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | 1 |
| 37859710 | 10.1039/d3md00355h | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine