Compound Detail
CHEMBL5289872
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Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCOCC(C)(COCCOCCOCCNC(=O)C[C@@H]1N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc31)COC(=O)NCCNc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2
Basic Information
| ChEMBL ID | CHEMBL5289872 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LNGAANLDNXHLFJ-UIJPAKTKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1490.6
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MV4-11 CHEMBL613835 | IC50 | 7.02 | 7.02 | 94.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MV4-11 | IC50 | = | 94.6 | nM | 7.02 | Antiproliferative activity against human MV4-11 cells | 35763424 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35763424 | 10.1021/acs.jmedchem.2c00728 | MV4-11 | 1 |
Data from ChEMBL 36 via Core Engine