Compound Detail
CHEMBL5291148
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Basic Information
| ChEMBL ID | CHEMBL5291148 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VWHZNFQPVUHMJV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
173.2
MW (Da)
1.23
ALogP
3
HBA
2
HBD
50.4
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Internal ribosome entry site (IRES) CHEMBL612412 | EC50 | 4.0 | 4.0 | 100000.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 100000.0 | nM | 4.0 | Inhibition of HCV RNA IRES IIa by FRET assay | 29656203 |
| Internal ribosome entry site (IRES) | EC50 | = | 100000.0 | nM | 4.0 | Binding affinity to HCV IRES subdomain IIa RNA by FRET assay | 38784459 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29656203 | 10.1016/j.ejmech.2018.03.076 | Unchecked | 1 |
| 38784459 | 10.1039/d3md00696d | Internal ribosome entry site (IRES) | 1 |
Data from ChEMBL 36 via Core Engine