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Compound Detail

CHEMBL5314413

LARTESERTIB
🧪 Phase II
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🧪 Phase II
COc1cc2ncc3c(c2cc1-c1cn(C)nc1C)n(-c1c(F)cncc1OC)c(=O)n3C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5314413
Name LARTESERTIB
Phase Phase II
Structure Type MOL
InChI Key WNEFOSMCGCLLJU-UHFFFAOYSA-N

Known Names

Lartesertib M 4076 M-4076 M4076
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
4
Known Names
1
Indications

Molecular Properties

448.5
MW (Da)
3.14
ALogP
9
HBA
0
HBD
89.0
PSA (Ų)
0.42
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer
USAN Stem -sertib

Extended Properties

Molecular Formula C23H21FN6O3
MW 448.46
Aromatic Rings 5
Heavy Atoms 33
NP-Likeness -0.96

Indications

Neoplasms

Activity Summary

IC50 2 meas. best 9.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine-protein kinase ATM
CHEMBL3797
 IC50 9.7 9.7 0.2 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Serine-protein kinase ATM IC50 = 0.2 nM 9.7 Inhibition of ATM (unknown origin) 37438997
Serine-protein kinase ATM IC50 = 0.2 nM 9.7 Inhibition of ATM (unknown origin) 38955347

Literature References

PubMed DOI Target Context # Activities
37438997 10.1021/acs.jmedchem.3c00082 Serine-protein kinase ATM 1
38955347 10.1021/acs.jmedchem.4c00113 Serine-protein kinase ATM 1

Data from ChEMBL 36 via Core Engine