Compound Detail
CHEMBL5314649
RITLECITINIB TOSYLATE 💊 Approved Drug
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💊 Approved Drug
C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C.Cc1ccc(S(=O)(=O)O)cc1
Basic Information
| ChEMBL ID | CHEMBL5314649 |
| Name | RITLECITINIB TOSYLATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | YOZLVAFWYLSRRN-VZXYPILPSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL4085457 |
| Active Moiety | CHEMBL4085457 |
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
5
Known Names
1
Indications
2
Mechanisms
Molecular Properties
285.4
MW (Da)
1.94
ALogP
4
HBA
2
HBD
73.9
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2023 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 inhibitor | INHIBITOR | Tyrosine-protein kinase JAK3 | ✓ | ✓ |
| TEC family kinase inhibitor | INHIBITOR | TEC family kinase | ✓ | ✓ |
Indications
Alopecia Areata
Drug Warnings
Black Box Warning
vascular toxicity
Black Box Warning
infectious disease
Black Box Warning
cardiotoxicity
Black Box Warning
carcinogenicity
Data from ChEMBL 36 via Core Engine