Compound Detail
CHEMBL5396635
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Cc1oc2nc1-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)C1=N[C@@H](CS1)c1nc-2c(C)o1
Basic Information
| ChEMBL ID | CHEMBL5396635 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YVSQVYZBDXIXCC-INIZCTEOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
582.5
MW (Da)
5.77
ALogP
16
HBA
0
HBD
194.6
PSA (Ų)
0.21
QED
3
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 500.0 | nM | 6.3 | Inhibition of telomerase (unknown origin) | 36669398 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36669398 | 10.1016/j.ejmech.2023.115121 | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine