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Compound Detail

CHEMBL5399464

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CN(C)CCOc1ccc(Cl)cc1NCc1cc2[nH]ccc2cc1Cl

Basic Information

ChEMBL ID CHEMBL5399464
Phase Preclinical
Structure Type MOL
InChI Key FCVSKIJVYDAFDD-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

378.3
MW (Da)
5.03
ALogP
3
HBA
2
HBD
40.3
PSA (Ų)
0.61
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H21Cl2N3O
MW 378.30
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -1.38

Activity Summary

EC50 1 meas. best 5.3
Kd 1 meas. best 5.75

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
Kd 5.75 5.75 1800.0 1
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
EC50 5.3 5.3 5000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37751901 10.1021/acs.jmedchem.3c00852 Nuclear receptor subfamily 4 group A member 2 3

Data from ChEMBL 36 via Core Engine