Compound Detail
CHEMBL5400126
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Basic Information
| ChEMBL ID | CHEMBL5400126 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QANUJVJMFPONSK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
435.5
MW (Da)
2.22
ALogP
6
HBA
1
HBD
71.1
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon CHEMBL3763008 | IC50 | 6.09 | 6.09 | 808.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 8.5 | mL.min-1.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon | IC50 | = | 808.0 | nM | 6.09 | Inhibition of N-terminal fused Nano Luc CRBN in HEK293T cells by NanoBRET CRBN e... | 38389883 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38389883 | 10.1039/d3md00652b | ADMET | 3 |
| 38389883 | 10.1039/d3md00652b | DNA-binding protein Ikaros | 2 |
| 38389883 | 10.1039/d3md00652b | Protein cereblon | 1 |
Data from ChEMBL 36 via Core Engine