Assay Detail
Binding
CHEMBL5380587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal fused Nano Luc CRBN in HEK293T cells by NanoBRET CRBN engagement assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.09 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279477 | — | — | 1 | 8.96 |
| CHEMBL3989927 | IBERDOMIDE | 3.0 | 1 | 7.89 |
| CHEMBL5431003 | — | — | 1 | 7.15 |
| CHEMBL304572 | — | — | 1 | 6.26 |
| CHEMBL5400126 | — | — | 1 | 6.09 |
| CHEMBL5397713 | — | — | 1 | 5.44 |
| CHEMBL5430028 | — | — | 1 | 5.07 |
| CHEMBL5427622 | — | — | 1 | 4.80 |
| CHEMBL5409036 | — | — | 1 | 4.64 |
| CHEMBL5425793 | — | — | 1 | 4.64 |
| CHEMBL5422831 | — | — | 1 | - |
| CHEMBL5419662 | — | — | 1 | - |
| CHEMBL5410477 | — | — | 1 | - |
| CHEMBL5425952 | — | — | 1 | - |
| CHEMBL5406424 | — | — | 1 | - |
| CHEMBL4633140 | — | — | 1 | - |
| CHEMBL5399582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279477 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3989927 | IBERDOMIDE | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL5431003 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL304572 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5400126 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL5397713 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5430028 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5427622 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5409036 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5425793 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5422831 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5419662 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5410477 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5425952 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5406424 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4633140 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5399582 | — | IC50 | > | 50000.0 | nM | - |