Compound Detail
CHEMBL5431003
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Basic Information
| ChEMBL ID | CHEMBL5431003 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CXFJUNPGGLCGBA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
312.3
MW (Da)
0.47
ALogP
5
HBA
1
HBD
83.5
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein cereblon CHEMBL3763008 | IC50 | 7.15 | 7.15 | 71.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein cereblon | IC50 | = | 71.0 | nM | 7.15 | Inhibition of N-terminal fused Nano Luc CRBN in HEK293T cells by NanoBRET CRBN e... | 38389883 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38389883 | 10.1039/d3md00652b | Protein cereblon | 1 |
| 38389883 | 10.1039/d3md00652b | DNA-binding protein Ikaros | 1 |
Data from ChEMBL 36 via Core Engine