Compound Detail
CHEMBL5401076
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Basic Information
| ChEMBL ID | CHEMBL5401076 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DIYAUQPRYJXPAG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
339.4
MW (Da)
1.98
ALogP
6
HBA
2
HBD
87.2
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 8.34 | 8.34 | 4.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 4.6 | nM | 8.34 | Inhibition of CSF1R (unknown origin) using FRET-peptide as substrate incubated i... | 37141705 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37141705 | 10.1016/j.ejmech.2023.115344 | Macrophage colony-stimulating factor 1 receptor | 2 |
| 37141705 | 10.1016/j.ejmech.2023.115344 | No relevant target | 1 |
| 37141705 | 10.1016/j.ejmech.2023.115344 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine