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Compound Detail

CHEMBL5406325

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CCCCN1CCC(CNC(=O)c2cc3[nH]ccc3cc2Cl)C1

Basic Information

ChEMBL ID CHEMBL5406325
Phase Preclinical
Structure Type MOL
InChI Key NSUUNGNNJGLAFM-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

333.9
MW (Da)
3.67
ALogP
2
HBA
2
HBD
48.1
PSA (Ų)
0.85
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H24ClN3O
MW 333.86
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -1.54

Activity Summary

EC50 1 meas. best 4.55
Kd 1 meas. best 4.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
Kd 4.8 4.8 16000.0 1
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
EC50 4.55 4.55 28000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37751901 10.1021/acs.jmedchem.3c00852 Nuclear receptor subfamily 4 group A member 2 3
37751901 10.1021/acs.jmedchem.3c00852 HEK-293T 1

Data from ChEMBL 36 via Core Engine