Compound Detail
CHEMBL5408840
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Basic Information
| ChEMBL ID | CHEMBL5408840 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XZPXEZUVJUGIDX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
420.8
MW (Da)
5.12
ALogP
3
HBA
0
HBD
42.4
PSA (Ų)
0.59
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase SIK2 CHEMBL5699 | IC50 | 5.01 | 5.01 | 9800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase SIK2 | IC50 | = | 9800.0 | nM | 5.01 | Inhibition of SIK2 (unknown origin) using AMARA as substrate buffer incubated fo... | 37467565 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37467565 | 10.1016/j.bmc.2023.117414 | Serine/threonine-protein kinase SIK2 | 1 |
Data from ChEMBL 36 via Core Engine