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Compound Detail

CHEMBL5408931

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C#CCn1c(=O)c2[nH]c(C(C)Cc3ccccc3)nc2n(CCCCP(=O)(O)O)c1=O

Basic Information

ChEMBL ID CHEMBL5408931
Phase Preclinical
Structure Type MOL
InChI Key OTPGGHSXFLAEBB-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

444.4
MW (Da)
1.82
ALogP
6
HBA
3
HBD
130.2
PSA (Ų)
0.26
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25N4O5P
MW 444.43
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.69

Activity Summary

EC50 4 meas. best 7.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 7.56 6.41 27.7 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37967029 10.1021/acs.jmedchem.3c01013 Unchecked 4

Data from ChEMBL 36 via Core Engine