Compound Detail
CHEMBL5411442
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CNc1cc(CN(CC2CCNCC2)S(=O)(=O)c2ccc(S(=O)(=O)N(Cc3ccc(Cl)cc3)C3CCCC3)cc2)ccc1C(=O)NCCOCCOCCNC(=O)COc1c(Br)cc(/C=C2\C(=O)Nc3ccc(I)cc32)cc1Br
Basic Information
| ChEMBL ID | CHEMBL5411442 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IOVSMYVIYAJIIV-KQJZZRHUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1380.5
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta CHEMBL3860 | Kd | 7.24 | 7.24 | 57.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Kd | = | 57.0 | nM | 7.24 | Binding affinity to PDEdelta (unknown origin) assessed as dissociation constant ... | 38229750 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38229750 | 10.1021/acsmedchemlett.3c00161 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 1 |
| 38229750 | 10.1021/acsmedchemlett.3c00161 | LC3-B-PDEdelta | 1 |
Data from ChEMBL 36 via Core Engine