Assay Detail
Binding
CHEMBL5359189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PDEdelta (unknown origin) assessed as dissociation constant incubated for overnight by fluorescence polarization assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (CHEMBL3860) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 7.19 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426895 | — | — | 1 | 8.03 |
| CHEMBL5415524 | — | — | 1 | 7.29 |
| CHEMBL5403101 | — | — | 1 | 7.28 |
| CHEMBL5439010 | — | — | 1 | 7.25 |
| CHEMBL5411442 | — | — | 1 | 7.24 |
| CHEMBL5419692 | — | — | 1 | 7.15 |
| CHEMBL5420032 | — | — | 1 | 7.14 |
| CHEMBL5406378 | — | — | 1 | 7.13 |
| CHEMBL5422170 | — | — | 1 | 7.13 |
| CHEMBL5413531 | — | — | 1 | 7.09 |
| CHEMBL5428558 | — | — | 1 | 7.09 |
| CHEMBL5408872 | — | — | 1 | 7.03 |
| CHEMBL5431289 | — | — | 1 | 6.94 |
| CHEMBL5425110 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426895 | — | Kd | = | 9.3 | nM | 8.03 |
| CHEMBL5415524 | — | Kd | = | 51.0 | nM | 7.29 |
| CHEMBL5403101 | — | Kd | = | 52.0 | nM | 7.28 |
| CHEMBL5439010 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL5411442 | — | Kd | = | 57.0 | nM | 7.24 |
| CHEMBL5419692 | — | Kd | = | 71.0 | nM | 7.15 |
| CHEMBL5420032 | — | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL5406378 | — | Kd | = | 74.0 | nM | 7.13 |
| CHEMBL5422170 | — | Kd | = | 74.0 | nM | 7.13 |
| CHEMBL5413531 | — | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL5428558 | — | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL5408872 | — | Kd | = | 94.0 | nM | 7.03 |
| CHEMBL5431289 | — | Kd | = | 116.0 | nM | 6.94 |
| CHEMBL5425110 | — | Kd | = | 153.0 | nM | 6.82 |