Compound Detail
CHEMBL5426895
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Basic Information
| ChEMBL ID | CHEMBL5426895 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OBRTYBUCNRKZPE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
443.6
MW (Da)
4.73
ALogP
5
HBA
1
HBD
62.5
PSA (Ų)
0.55
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 8.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta CHEMBL3860 | Kd | 8.03 | 8.03 | 9.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Kd | = | 9.3 | nM | 8.03 | Binding affinity to PDEdelta (unknown origin) assessed as dissociation constant ... | 38229750 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38229750 | 10.1021/acsmedchemlett.3c00161 | MIA PaCa-2 | 4 |
| 38229750 | 10.1021/acsmedchemlett.3c00161 | CAPAN-1 | 1 |
| 38229750 | 10.1021/acsmedchemlett.3c00161 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 1 |
Data from ChEMBL 36 via Core Engine