Compound Detail
CHEMBL5411764
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Basic Information
| ChEMBL ID | CHEMBL5411764 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YPBYUORMVUNGBN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
289.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Replicase polyprotein 1ab CHEMBL4523582 | IC50 | 6.54 | 6.54 | 287.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Replicase polyprotein 1ab | IC50 | = | 287.0 | nM | 6.54 | Inhibition of SARS-CoV-2 MPro using protease substrate preincubated with enzyme ... | 37972434 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37972434 | 10.1016/j.bmc.2023.117531 | Replicase polyprotein 1ab | 4 |
| 37972434 | 10.1016/j.bmc.2023.117531 | Cathepsin K | 2 |
| 37972434 | 10.1016/j.bmc.2023.117531 | Cathepsin B | 1 |
| 37972434 | 10.1016/j.bmc.2023.117531 | SARS-CoV-2 | 1 |
| 37972434 | 10.1016/j.bmc.2023.117531 | Vero C1008 | 1 |
Data from ChEMBL 36 via Core Engine