Compound Detail
CHEMBL5416254
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Basic Information
| ChEMBL ID | CHEMBL5416254 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YLYUWDAVNNVJLE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
256.3
MW (Da)
1.39
ALogP
3
HBA
0
HBD
40.6
PSA (Ų)
0.76
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | EC50 | 4.24 | 4.24 | 57544.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic AMPA | EC50 | = | 57543.99 | nM | 4.24 | Positive allosteric modulation at AMPAR in HEK293 cells expressing GluA2Q assess... | 36863228 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36863228 | 10.1016/j.ejmech.2023.115221 | Glutamate receptor ionotropic, AMPA | 2 |
| 36863228 | 10.1016/j.ejmech.2023.115221 | Glutamate receptor ionotropic AMPA | 1 |
Data from ChEMBL 36 via Core Engine