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Compound Detail

CHEMBL5416432

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CN(C)CCOc1ccc(Cl)cc1NC(=O)c1cc2c(ccn2C)cc1Cl

Basic Information

ChEMBL ID CHEMBL5416432
Phase Preclinical
Structure Type MOL
InChI Key YLMVVXSCNHLBJI-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

406.3
MW (Da)
4.68
ALogP
4
HBA
1
HBD
46.5
PSA (Ų)
0.65
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H21Cl2N3O2
MW 406.31
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.71

Activity Summary

EC50 1 meas. best 4.8
Kd 1 meas. best 6.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
Kd 6.0 6.0 1000.0 1
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
EC50 4.8 4.8 16000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37751901 10.1021/acs.jmedchem.3c00852 Nuclear receptor subfamily 4 group A member 2 3

Data from ChEMBL 36 via Core Engine