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Compound Detail

CHEMBL5419791

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Clc1ccc(-c2nc3ccccn3c2-c2cn(Cc3ccccc3)nn2)cc1

Basic Information

ChEMBL ID CHEMBL5419791
Phase Preclinical
Structure Type MOL
InChI Key YBNBIEVJASHXAQ-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

385.9
MW (Da)
4.96
ALogP
5
HBA
0
HBD
48.0
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H16ClN5
MW 385.86
Aromatic Rings 5
Heavy Atoms 28
NP-Likeness -2.04

Activity Summary

EC50 3 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 1 group I member 3
CHEMBL5503
EC50 9.0 7.67 1.0 2
Nuclear receptor subfamily 1 group I member 2
CHEMBL3401
EC50 5.69 5.69 2060.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36756805 10.1021/acs.jmedchem.2c01140 Nuclear receptor subfamily 1 group I member 3 2
36756805 10.1021/acs.jmedchem.2c01140 Nuclear receptor subfamily 1 group I member 2 2
36756805 10.1021/acs.jmedchem.2c01140 Unchecked 1

Data from ChEMBL 36 via Core Engine