Nuclear receptor subfamily 1 group I member 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q14994. Use UniProt Q14994 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14994 as the stable identity anchor, then attach disease evidence before program review.
Nuclear receptor subfamily 1 group I member 3
Review this target as Nuclear receptor subfamily 1 group I member 3, mapped to UniProt Q14994. Sequence length is 352 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nuclear receptor subfamily 1 group I member 3 as ChEMBL target CHEMBL5503, mapped to UniProt Q14994. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Nuclear receptor subfamily 1 group I member 3 is the right protein anchor across sources, using UniProt Q14994 as the stable mapping.
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| Preferred Name | Nuclear receptor subfamily 1 group I member 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14994 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nuclear receptor subfamily 1 group I member 3 |
| UniProt Accession | Q14994 |
| Component Type | Protein |
| Sequence Length | 352 aa |
Nuclear receptor subfamily 1 group I member 3
Review this target as Nuclear receptor subfamily 1 group I member 3, mapped to UniProt Q14994. Sequence length is 352 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5400735 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5419791 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5426747 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5429867 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5434244 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5396305 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL5439022 | 8.7 | EC50 | 2.0 | Preclinical |
| CHEMBL5408637 | 8.52 | EC50 | 3.0 | Preclinical |
| CHEMBL5425742 | 8.4 | EC50 | 4.0 | Preclinical |
| CHEMBL458603 | 8.3 | EC50 | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 87 | 95 | 6.0 |
| single protein format | 16 | 104 | 6.9 |
| assay format | 1 | 1 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 0 | — |
| single protein format | 5 | 0 | — |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 2 | 6.7 |
| assay format | 1 | 0 | — |