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Compound Detail

CHEMBL5439022

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Clc1ccc(Cn2cc(-c3c(-c4ccc(Cl)cc4)nc4ccccn34)nn2)cc1

Basic Information

ChEMBL ID CHEMBL5439022
Phase Preclinical
Structure Type MOL
InChI Key VZXZJFDWEQJFAB-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

420.3
MW (Da)
5.61
ALogP
5
HBA
0
HBD
48.0
PSA (Ų)
0.38
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H15Cl2N5
MW 420.30
Aromatic Rings 5
Heavy Atoms 29
NP-Likeness -1.95

Activity Summary

EC50 2 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 1 group I member 3
CHEMBL5503
EC50 8.7 8.0 2.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36756805 10.1021/acs.jmedchem.2c01140 Nuclear receptor subfamily 1 group I member 3 2
36756805 10.1021/acs.jmedchem.2c01140 Nuclear receptor subfamily 1 group I member 2 1
36756805 10.1021/acs.jmedchem.2c01140 Unchecked 1

Data from ChEMBL 36 via Core Engine