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Compound Detail

CHEMBL5420073

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C#CCn1c(=O)c2[nH]c(CCc3cccc(OC)c3)nc2n(CCCCP(=O)(O)O)c1=O

Basic Information

ChEMBL ID CHEMBL5420073
Phase Preclinical
Structure Type MOL
InChI Key RZWIZKOWQADYEW-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names

Molecular Properties

460.4
MW (Da)
1.27
ALogP
7
HBA
3
HBD
139.4
PSA (Ų)
0.24
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25N4O6P
MW 460.43
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.92

Activity Summary

EC50 4 meas. best 7.95

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 7.95 6.7625 11.2 4

Pharmacokinetic Data

Parameter Value Units Species
T1/2 4.5 hr Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37967029 10.1021/acs.jmedchem.3c01013 Unchecked 4
37967029 10.1021/acs.jmedchem.3c01013 ADMET 2
37967029 10.1021/acs.jmedchem.3c01013 LN-229 1
37967029 10.1021/acs.jmedchem.3c01013 No relevant target 1

Data from ChEMBL 36 via Core Engine