Compound Detail
CHEMBL542103
NEVANIMIBE HYDROCHLORIDE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL542103 |
| Name | NEVANIMIBE HYDROCHLORIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | SDOOGTHIDFZUNM-UHFFFAOYSA-N |
| Parent Compound | CHEMBL46423 |
| Active Moiety | CHEMBL46423 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
9
Known Names
2
Indications
Molecular Properties
421.6
MW (Da)
6.63
ALogP
2
HBA
2
HBD
44.4
PSA (Ų)
0.53
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Adrenal Hyperplasia, Congenital Cushing Syndrome
Activity Summary
IC50 2 meas. best 7.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.28 | 7.28 | 52.0 | 1 |
| Acyl-CoA:cholesterol acyltransferase CHEMBL6141 | IC50 | 7.28 | 7.28 | 52.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acyl-CoA:cholesterol acyltransferase | IC50 | = | 52.0 | nM | 7.28 | Tested for in vitro inhibition against Acyl coenzyme A:cholesterol acyltransfera... | 8201599 |
| Unchecked | IC50 | = | 52.0 | nM | 7.28 | Inhibition of small intimal microsomal fraction of cholesterol-fed rabbit ACAT u... | 36473091 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8201599 | 10.1021/jm00037a016 | Rattus norvegicus | 31 |
| 8201599 | 10.1021/jm00037a016 | No relevant target | 3 |
| 8201599 | 10.1021/jm00037a016 | Acyl-CoA:cholesterol acyltransferase | 1 |
| 36473091 | 10.1021/acs.jmedchem.2c01265 | Unchecked | 1 |
| 36473091 | 10.1021/acs.jmedchem.2c01265 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine