Compound Detail
CHEMBL5424226
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Basic Information
| ChEMBL ID | CHEMBL5424226 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GGXOWSHRSUEALX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
443.5
MW (Da)
1.58
ALogP
10
HBA
2
HBD
141.0
PSA (Ų)
0.50
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kinesin-like protein KIFC1 CHEMBL3351200 | IC50 | 7.57 | 7.32 | 27.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kinesin-like protein KIFC1 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of N-terminal His-tagged full length recombinant human HSET assessed ... | 36749938 |
| Kinesin-like protein KIFC1 | IC50 | = | 86.0 | nM | 7.07 | Inhibition of N-terminal His-tagged full length recombinant human HSET assessed ... | 36749938 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36749938 | 10.1021/acs.jmedchem.2c01591 | Kinesin-like protein KIFC1 | 2 |
| 36749938 | 10.1021/acs.jmedchem.2c01591 | Unchecked | 2 |
| 36749938 | 10.1021/acs.jmedchem.2c01591 | Kinesin-like protein KIF11 | 1 |
Data from ChEMBL 36 via Core Engine