Compound Detail
CHEMBL5424693
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Basic Information
| ChEMBL ID | CHEMBL5424693 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DCALUXGQDNMVKL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
2.17
ALogP
3
HBA
0
HBD
37.4
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MOLP-8 CHEMBL5308502 | IC50 | 4.07 | 4.07 | 85870.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MOLP-8 | IC50 | = | 85870.0 | nM | 4.07 | Antiproliferative activity against human MOLP8 cells assessed as inhibition of c... | 36476642 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36476642 | 10.1016/j.ejmech.2022.114990 | Protein cereblon | 1 |
| 36476642 | 10.1016/j.ejmech.2022.114990 | MOLP-8 | 1 |
| 36476642 | 10.1016/j.ejmech.2022.114990 | KMS-12-PE | 1 |
Data from ChEMBL 36 via Core Engine