Assay Detail
Functional
CHEMBL5355406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MOLP8 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CellTiter Glo luminescence based MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLP-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.69 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5429778 | — | — | 1 | 5.28 |
| CHEMBL5404837 | — | — | 1 | 5.26 |
| CHEMBL5416620 | — | — | 1 | 5.24 |
| CHEMBL5422899 | — | — | 1 | 5.24 |
| CHEMBL5418383 | — | — | 1 | 5.20 |
| CHEMBL5397775 | — | — | 1 | 5.17 |
| CHEMBL5435497 | — | — | 1 | 5.07 |
| CHEMBL5436049 | — | — | 1 | 4.92 |
| CHEMBL5439702 | — | — | 1 | 4.89 |
| CHEMBL5409302 | — | — | 1 | 4.80 |
| CHEMBL5418463 | — | — | 1 | 4.74 |
| CHEMBL5413097 | — | — | 1 | 4.70 |
| CHEMBL5418739 | — | — | 1 | 4.69 |
| CHEMBL5419971 | — | — | 1 | 4.68 |
| CHEMBL5398118 | — | — | 1 | 4.62 |
| CHEMBL5435385 | — | — | 1 | 4.56 |
| CHEMBL5436622 | — | — | 1 | 4.56 |
| CHEMBL5413552 | — | — | 1 | 4.50 |
| CHEMBL5404825 | — | — | 1 | 4.49 |
| CHEMBL5419709 | — | — | 1 | 4.42 |
| CHEMBL5406302 | — | — | 1 | 4.42 |
| CHEMBL5428083 | — | — | 1 | 4.40 |
| CHEMBL5397580 | — | — | 1 | 4.39 |
| CHEMBL5411137 | — | — | 1 | 4.35 |
| CHEMBL5434742 | — | — | 1 | 4.30 |
| CHEMBL5418032 | — | — | 1 | 4.14 |
| CHEMBL5408086 | — | — | 1 | 4.09 |
| CHEMBL5424693 | — | — | 1 | 4.07 |
| CHEMBL5406576 | — | — | 1 | - |
| CHEMBL5435212 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5429778 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5404837 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL5416620 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL5422899 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5418383 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL5397775 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL5435497 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL5436049 | — | IC50 | = | 11930.0 | nM | 4.92 |
| CHEMBL5439702 | — | IC50 | = | 12850.0 | nM | 4.89 |
| CHEMBL5409302 | — | IC50 | = | 15880.0 | nM | 4.80 |
| CHEMBL5418463 | — | IC50 | = | 18280.0 | nM | 4.74 |
| CHEMBL5413097 | — | IC50 | = | 19830.0 | nM | 4.70 |
| CHEMBL5418739 | — | IC50 | = | 20490.0 | nM | 4.69 |
| CHEMBL5419971 | — | IC50 | = | 21020.0 | nM | 4.68 |
| CHEMBL5398118 | — | IC50 | = | 23940.0 | nM | 4.62 |
| CHEMBL5436622 | — | IC50 | = | 27370.0 | nM | 4.56 |
| CHEMBL5435385 | — | IC50 | = | 27390.0 | nM | 4.56 |
| CHEMBL5413552 | — | IC50 | = | 31990.0 | nM | 4.50 |
| CHEMBL5404825 | — | IC50 | = | 32340.0 | nM | 4.49 |
| CHEMBL5419709 | — | IC50 | = | 38320.0 | nM | 4.42 |
| CHEMBL5406302 | — | IC50 | = | 38150.0 | nM | 4.42 |
| CHEMBL5428083 | — | IC50 | = | 39980.0 | nM | 4.40 |
| CHEMBL5397580 | — | IC50 | = | 41160.0 | nM | 4.39 |
| CHEMBL5411137 | — | IC50 | = | 44260.0 | nM | 4.35 |
| CHEMBL5434742 | — | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL5418032 | — | IC50 | = | 73190.0 | nM | 4.14 |
| CHEMBL5408086 | — | IC50 | = | 80830.0 | nM | 4.09 |
| CHEMBL5424693 | — | IC50 | = | 85870.0 | nM | 4.07 |
| CHEMBL5406576 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5435212 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5402303 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5420053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL468 | THALIDOMIDE | IC50 | > | 75000.0 | nM | - |