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Compound Detail

CHEMBL542561

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C#CCOC(=O)C1CN=C(N)NC1.Cl

Basic Information

ChEMBL ID CHEMBL542561
Phase Preclinical
Structure Type MOL
InChI Key FGSNZOYXRJRPFN-UHFFFAOYSA-N
Parent Compound CHEMBL1191457
Active Moiety CHEMBL1191457
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

181.2
MW (Da)
-1.30
ALogP
5
HBA
2
HBD
76.7
PSA (Ų)
0.41
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H12ClN3O2
MW 217.66
Aromatic Rings 0
Heavy Atoms 13
NP-Likeness 0.24

Activity Summary

EC50 1 meas.
IC50 1 meas. best 4.51

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 4.51 4.51 31000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9111297 10.1021/jm960467d Muscarinic acetylcholine receptor M1 2
8064804 10.1021/jm00043a016 Muscarinic acetylcholine receptor 1
8064804 10.1021/jm00043a016 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine