Compound Detail
CHEMBL5429895
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5429895 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SCMNLNKBTHTQIH-SFHVURJKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
397.4
MW (Da)
3.46
ALogP
4
HBA
1
HBD
54.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL259 | IC50 | 8.42 | 8.42 | 3.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | IC50 | = | 3.8 | nM | 8.42 | Antagonist activity at human MC4R in CHO cells measured for 24 hrs | 36802610 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36802610 | 10.1021/acs.jmedchem.2c02012 | Melanocortin receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine