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Compound Detail

CHEMBL5433920

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O=C1[C@@H]2CCCN2[C@@H](c2ccc([C@H]3C[C@@H](O)[C@@H](CO)O3)cc2)N1c1ccc([N+](=O)[O-])cc1

Basic Information

ChEMBL ID CHEMBL5433920
Phase Preclinical
Structure Type MOL
InChI Key XIYFEFKDZSNVNN-ZSYZGHEHSA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

439.5
MW (Da)
2.29
ALogP
7
HBA
2
HBD
116.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25N3O6
MW 439.47
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness 0.18

Activity Summary

EC50 6 meas. best 5.65

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Zika virus
CHEMBL4296612
EC50 5.65 5.3833 2260.0 3
Usutu virus
CHEMBL4296609
EC50 5.6 5.4 2530.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine