Compound Detail
CHEMBL5435814
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Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C[C@@H](NC(=O)CCCCCCCCCCn2cc(COc3cc4ncnc(Nc5ccc(F)c(Cl)c5)c4cc3NC(=O)/C=C/CN3CCCCC3)nn2)C(C)(C)C)cc1
Basic Information
| ChEMBL ID | CHEMBL5435814 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QAEXHMQGWKYICT-RSKMNCKASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1119.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.45
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/EGFR CHEMBL4523998 | EC50 | 8.45 | 8.45 | 3.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/EGFR | EC50 | = | 3.57 | nM | 8.45 | Protac activity at VHL/EGFR deletion19 mutant in human HCC827 cells assessed as ... | 36812395 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36812395 | 10.1021/acs.jmedchem.2c01242 | von Hippel-Lindau disease tumor suppressor/EGFR | 2 |
Data from ChEMBL 36 via Core Engine