von Hippel-Lindau disease tumor suppressor/EGFR · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P00533. Use UniProt P00533 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00533 as the stable identity anchor, then attach disease evidence before program review.
Epidermal growth factor receptor
Review this target as von Hippel-Lindau disease tumor suppressor/EGFR, mapped to UniProt P00533. ChEMBL maps the protein component as Epidermal growth factor receptor. Sequence length is 1210 aa.
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This review treats von Hippel-Lindau disease tumor suppressor/EGFR as ChEMBL target CHEMBL4523998, mapped to UniProt P00533. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | von Hippel-Lindau disease tumor suppressor/EGFR |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P00533 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Epidermal growth factor receptor |
| UniProt Accession | P00533 |
| Component Type | Protein |
| Sequence Length | 1210 aa |
Epidermal growth factor receptor
Review this target as von Hippel-Lindau disease tumor suppressor/EGFR, mapped to UniProt P00533. ChEMBL maps the protein component as Epidermal growth factor receptor. Sequence length is 1210 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3353410 | 9.0 | IC50 | 1.0 | Approved |
| CHEMBL5435814 | 8.45 | EC50 | 3.57 | Preclinical |
| CHEMBL5202214 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4587573 | 7.93 | EC50 | 11.7 | Preclinical |
| CHEMBL5185820 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL5277193 | 7.41 | EC50 | 39.2 | Preclinical |
| CHEMBL5175569 | 6.67 | EC50 | 215.8 | Preclinical |
| CHEMBL5202759 | 6.07 | IC50 | 857.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 234 | 4 | 7.6 |
| subcellular format | 7 | 0 | — |
| protein format | 2 | 4 | 7.8 |