Compound Detail
CHEMBL5175569
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Cc1ccsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc2NC(=O)/C=C/CN(C)C)C(C)(C)C)cc1
Basic Information
| ChEMBL ID | CHEMBL5175569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UNRCLAHHNLDXHT-SBVKIVAMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1085.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/EGFR CHEMBL4523998 | EC50 | 6.67 | 6.67 | 215.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| von Hippel-Lindau disease tumor suppressor/EGFR | EC50 | = | 215.8 | nM | 6.67 | Protac activity at VHL/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed... | 35691176 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35691176 | 10.1016/j.ejmech.2022.114509 | von Hippel-Lindau disease tumor suppressor/EGFR | 1 |
Data from ChEMBL 36 via Core Engine