Assay Detail
Binding
CHEMBL5116677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protac activity at VHL/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of degradation of EGFR incubated for 24 hrs in presence of afatinib by immunoblot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
von Hippel-Lindau disease tumor suppressor/EGFR (CHEMBL4523998) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of highly potent and selective CRBN-recruiting EGFR<sup>L858R/T790M</sup> degraders in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.67 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175569 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175569 | — | EC50 | = | 215.8 | nM | 6.67 |