Compound Detail
CHEMBL5437266
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Basic Information
| ChEMBL ID | CHEMBL5437266 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AUPQCDZQEXHWDC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
502.6
MW (Da)
3.71
ALogP
9
HBA
3
HBD
117.7
PSA (Ų)
0.40
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL2010622 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leucine-rich repeat serine/threonine-protein kinase 2 | IC50 | = | 190.0 | nM | 6.72 | Inhibition of mouse LRRK2 | 37201428 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37201428 | 10.1016/j.ejmech.2023.115475 | Leucine-rich repeat serine/threonine-protein kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine