Leucine-rich repeat serine/threonine-protein kinase 2 · SINGLE PROTEIN · Mus musculus
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q5S006. Use UniProt Q5S006 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5S006 as the stable identity anchor, then attach disease evidence before program review.
Leucine-rich repeat serine/threonine-protein kinase 2
Review this target as Leucine-rich repeat serine/threonine-protein kinase 2, mapped to UniProt Q5S006. Sequence length is 2527 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Leucine-rich repeat serine/threonine-protein kinase 2 as ChEMBL target CHEMBL2010622, mapped to UniProt Q5S006. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Leucine-rich repeat serine/threonine-protein kinase 2 is the right protein anchor across sources, using UniProt Q5S006 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Leucine-rich repeat serine/threonine-protein kinase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q5S006 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Leucine-rich repeat serine/threonine-protein kinase 2 |
| UniProt Accession | Q5S006 |
| Component Type | Protein |
| Sequence Length | 2527 aa |
Leucine-rich repeat serine/threonine-protein kinase 2
Review this target as Leucine-rich repeat serine/threonine-protein kinase 2, mapped to UniProt Q5S006. Sequence length is 2527 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4098877 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL5087055 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL5092087 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL4098877 | 7.52 | EC50 | 30.0 | Preclinical |
| CHEMBL5437266 | 6.72 | IC50 | 190.0 | Preclinical |
| CHEMBL5170238 | 6.58 | EC50 | 260.0 | Preclinical |
| CHEMBL5181966 | 6.55 | EC50 | 280.0 | Preclinical |
| CHEMBL5177578 | 6.54 | EC50 | 290.0 | Preclinical |
| CHEMBL5173029 | 6.47 | EC50 | 340.0 | Preclinical |
| CHEMBL5172291 | 6.41 | EC50 | 390.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 21 | 38 | 5.6 |
| assay format | 3 | 0 | — |
| organism-based format | 2 | 2 | 7.8 |
| single protein format | 1 | 1 | 6.7 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 27 | 1 | 8.4 |