Compound Detail

CHEMBL5170238

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

CCc1cc(-c2c(-c3ccncc3)n[nH]c2C)ccc1-c1cccc(S(N)(=O)=O)c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5170238
Phase	Preclinical
Structure Type	MOL
InChI Key	MFDUTXMPNQGZAQ-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

418.5

MW (Da)

4.32

ALogP

HBA

HBD

101.7

PSA (Å²)

0.50

QED

Ro5 Violations

Rot. Bonds

Availability	Unknown
Chirality	Unknown

First in Class Prodrug

IC50 2 meas. best 8.66

EC50 1 meas. best 6.58

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL1075104	IC50	8.66	8.18	2.2	2
Leucine-rich repeat serine/threonine-protein kinase 2 CHEMBL2010622	EC50	6.58	6.58	260.0	1

Parameter	Value	Units	Species
T1/2	0.3167	hr	Mus musculus
T1/2	1.983	hr	Homo sapiens

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Leucine-rich repeat serine/threonine-protein kinase 2	IC50	=	2.2	nM	8.66	Inhibition of full-length LRRK2 G2019S mutant (unknown origin) using LRRKtide as...	35707141
Leucine-rich repeat serine/threonine-protein kinase 2	IC50	=	19.9	nM	7.7	Inhibition of full-length wild type LRRK2 (unknown origin) using LRRKtide as sub...	35707141
Leucine-rich repeat serine/threonine-protein kinase 2	EC50	=	260.0	nM	6.58	Inhibition of mouse full-length LRRK2 G2019S mutant transfected in HEK293 cells ...	35707141

PubMed	DOI	Target Context	# Activities
35707141	10.1021/acsmedchemlett.2c00116	ADMET	5
35707141	10.1021/acsmedchemlett.2c00116	Leucine-rich repeat serine/threonine-protein kinase 2	4
35707141	10.1021/acsmedchemlett.2c00116	Unchecked	2

Data from ChEMBL 36 via Core Engine