Compound Detail
CHEMBL5437525
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Basic Information
| ChEMBL ID | CHEMBL5437525 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CUPCGRKHOAWCTI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
466.5
MW (Da)
4.98
ALogP
6
HBA
1
HBD
59.4
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A CHEMBL2717 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | IC50 | = | 0.7 | nM | 9.15 | Inhibition of PDE11A (unknown origin) | 37862143 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37862143 | 10.1021/acs.jmedchem.3c01088 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | 1 |
Data from ChEMBL 36 via Core Engine