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Compound Detail

CHEMBL5440972

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C/C(=C\CC/C(C)=C/CNCCNC1C2CC3CC(C2)CC1C3)CO

Basic Information

ChEMBL ID CHEMBL5440972
Phase Preclinical
Structure Type MOL
InChI Key GOVSQCSIWLLDJA-GMUNBBEISA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

346.6
MW (Da)
3.66
ALogP
3
HBA
3
HBD
44.3
PSA (Ų)
0.42
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H38N2O
MW 346.56
Aromatic Rings 0
Heavy Atoms 25
NP-Likeness 1.05

Activity Summary

IC50 3 meas. best 4.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cell membrane
CHEMBL2364031
IC50 4.77 4.77 17000.0 1
Mycolicibacterium smegmatis
CHEMBL613088
IC50 4.7 4.66 20000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37235809 10.1021/acs.jmedchem.3c00398 Mycolicibacterium smegmatis 3
37235809 10.1021/acs.jmedchem.3c00398 Mycobacterium tuberculosis 1
37235809 10.1021/acs.jmedchem.3c00398 Cell membrane 1

Data from ChEMBL 36 via Core Engine