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Assay Detail

CHEMBL5333911

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Functional
Antimycobacterial activity against Mycobacterium smegmatis assessed as inhibition of mycobacterial growth incubated for 48 hrs
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycolicibacterium smegmatis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycolicibacterium smegmatis (CHEMBL613088)
Type ORGANISM
Organism Mycolicibacterium smegmatis

Publication

Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, Oldfield E.
J Med Chem (2023) 66 : 7553 -7569
PubMed 37235809 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.11 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3261880 1 5.89
CHEMBL561057 SQ109 2.0 1 5.82
CHEMBL5403488 1 5.72
CHEMBL5395162 1 5.57
CHEMBL5432995 1 5.41
CHEMBL1197357 1 5.30
CHEMBL3261881 1 5.14
CHEMBL5414003 1 5.10
CHEMBL1087059 1 5.03
CHEMBL1798027 1 4.96
CHEMBL5400618 1 4.96
CHEMBL5412119 1 4.85
CHEMBL5440972 1 4.70
CHEMBL5415415 1 4.58
CHEMBL1197319 1 4.38
CHEMBL5424336 1 4.38
CHEMBL5435690 1 -
CHEMBL2041316 1 -
CHEMBL1170792 1 -
CHEMBL5407768 1 -
CHEMBL5417290 1 -
CHEMBL5394616 1 -
CHEMBL5440305 1 -
CHEMBL170190 1 -
CHEMBL1080997 CITRAL 1 -
CHEMBL5433745 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3261880 IC50 = 1300.0 nM 5.89
CHEMBL561057 SQ109 IC50 = 1500.0 nM 5.82
CHEMBL5403488 IC50 = 1900.0 nM 5.72
CHEMBL5395162 IC50 = 2700.0 nM 5.57
CHEMBL5432995 IC50 = 3900.0 nM 5.41
CHEMBL1197357 IC50 = 5000.0 nM 5.30
CHEMBL3261881 IC50 = 7300.0 nM 5.14
CHEMBL5414003 IC50 = 8000.0 nM 5.10
CHEMBL1087059 IC50 = 9300.0 nM 5.03
CHEMBL1798027 IC50 = 11000.0 nM 4.96
CHEMBL5400618 IC50 = 11000.0 nM 4.96
CHEMBL5412119 IC50 = 14000.0 nM 4.85
CHEMBL5440972 IC50 = 20000.0 nM 4.70
CHEMBL5415415 IC50 = 26000.0 nM 4.58
CHEMBL1197319 IC50 = 42000.0 nM 4.38
CHEMBL5424336 IC50 = 42000.0 nM 4.38
CHEMBL5435690 IC50 > 500000.0 nM -
CHEMBL2041316 IC50 > 500000.0 nM -
CHEMBL1170792 IC50 > 500000.0 nM -
CHEMBL5407768 IC50 > 500000.0 nM -
CHEMBL5417290 IC50 > 500000.0 nM -
CHEMBL5394616 IC50 > 500000.0 nM -
CHEMBL5440305 IC50 > 500000.0 nM -
CHEMBL170190 IC50 > 500000.0 nM -
CHEMBL1080997 CITRAL IC50 > 500000.0 nM -
CHEMBL5433745 IC50 > 500000.0 nM -