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Compound Detail

CHEMBL5412119

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c1ccc(CCNC2CCCc3c2[nH]c2ccc(C4CCCCC4)cc32)cc1

Basic Information

ChEMBL ID CHEMBL5412119
Phase Preclinical
Structure Type MOL
InChI Key UOXHIMPHQIDOBD-UHFFFAOYSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

372.6
MW (Da)
6.43
ALogP
1
HBA
2
HBD
27.8
PSA (Ų)
0.53
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H32N2
MW 372.56
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.15

Activity Summary

IC50 3 meas. best 4.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycolicibacterium smegmatis
CHEMBL613088
IC50 4.85 4.65 14000.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37235809 10.1021/acs.jmedchem.3c00398 Mycolicibacterium smegmatis 3
37467619 10.1016/j.ejmech.2023.115627 Staphylococcus aureus 1
37467619 10.1016/j.ejmech.2023.115627 Bacillus subtilis 1
37467619 10.1016/j.ejmech.2023.115627 Staphylococcus simulans 1
37467619 10.1016/j.ejmech.2023.115627 Enterococcus faecium 1
37467619 10.1016/j.ejmech.2023.115627 Moraxella catarrhalis 1

Data from ChEMBL 36 via Core Engine